| Pair Name | Silibinin, Paclitaxel | ||
| Phytochemical Name | Silibinin (PubChem CID: 31553 ) | ||
| Anticancer drug Name | Paclitaxel (PubChem CID: 36314 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Silibinin, Paclitaxel | |||
| Disease Info | [ICD-11: 2C73] | Ovarian cancer | Investigative | |
| Gene Regulation | Up-regulation | Expression | CDKN1A | hsa1026 |
| Up-regulation | Expression | TP53 | hsa7157 | |
| In Vitro Model | SK-OV-3 | Ovarian serous cystadenocarcinoma | Homo sapiens (Human) | CVCL_0532 |
| Result | Our results showed that combination of chemotherapy drugs of silibinin and paclitaxel can be more efficient in treatment of ovarian cancer cells. | |||
| Pair Name | Silibinin, Paclitaxel | |||
| Disease Info | [ICD-11: 2B72] | Gastric cancer | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in G2/M phase | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Cleavage | CASP8 | hsa841 | |
| Down-regulation | Expression | CCNB1 | hsa891 | |
| Down-regulation | Expression | CDC25C | hsa995 | |
| Down-regulation | Expression | CDK1 | hsa983 | |
| Up-regulation | Expression | FAS | hsa355 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| In Vitro Model | BGC-823 | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_3360 |
| SGC-7901 | Human papillomavirus-related cervical adenocarcinoma | Homo sapiens (Human) | CVCL_0520 | |
| AGS | Gastric adenocarcinoma | Homo sapiens (Human) | CVCL_0139 | |
| Result | Synergistic apoptotic effects of silibinin in enhancing paclitaxel toxicity in human gastric cancer cell lines | |||
| No. | Title | Href |
|---|---|---|
| 1 | Enhancement of anticancer activity by silibinin and paclitaxel combination on the ovarian cancer. Artif Cells Nanomed Biotechnol. 2018 Nov;46(7):1483-1487. doi: 10.1080/21691401.2017.1374281. | Click |
| 2 | Synergistic apoptotic effects of silibinin in enhancing paclitaxel toxicity in human gastric cancer cell lines. Mol Med Rep. 2018 Aug;18(2):1835-1841. doi: 10.3892/mmr.2018.9129. | Click |
